Preheat the oven to 350°F. Spray a 13x9-inch or larger casserole dish with nonstick spray.
Cut the whole chicken wings into 3 sections each; discard the wing tip section. Pat the wings dry with paper towels and season all over with salt and pepper.
In a medium bowl, whisk together 1 cup honey, ½ cup soy sauce, 2 tablespoons vegetable or canola oil, 2 tablespoons ketchup, the 3 minced garlic cloves, and ¼ teaspoon cayenne pepper until smooth.
Place the seasoned wings in the prepared casserole (in as close to a single layer as practical). Pour the sauce over the wings and toss gently to coat evenly.
Bake uncovered in the preheated oven until the wings are cooked through and the sauce is thickened and caramelized, about 45–60 minutes. Turn the wings and baste with the pan sauce every 15–20 minutes for even browning.
If desired for extra caramelization, broil for the last 2–4 minutes—watch closely to prevent burning.
Remove from the oven and let the wings rest about 5 minutes before serving.
Notes
If you are preparing this recipe asGLUTEN FREE, just be sure to use brands of soy sauce and ketchup that are known to be GF.