Preheat the oven to 425°F. Line a baking sheet with parchment paper.
Arrange the potato slices in a single layer on the prepared baking sheet. Drizzle the 1 tablespoon olive oil evenly over the slices and sprinkle with 1 teaspoon kosher salt and 1/2 teaspoon ground black pepper.
Bake the potato slices until tender throughout, about 30 minutes.
While the potatoes bake, thinly slice or shred the 1 pound boneless roast beef. Place it in a medium skillet over medium heat and warm, stirring, until heated through. Stir in the 1 teaspoon taco seasoning and mix until the beef is evenly seasoned; remove from heat.
When the potato slices are done, remove the baking sheet from the oven. Spoon the warmed, seasoned roast beef evenly over the baked potatoes.
Evenly distribute the 8 ounces shredded cheddar cheese and the 8 ounces mozzarella cheese over the beef-topped potatoes.
Move an oven rack to about 6 inches from the broiler, switch the oven setting to broil, and broil the nachos until the cheeses have melted and begin to bubble, about 3 to 5 minutes. Watch closely to avoid burning.
Remove from the oven and immediately top with Pico de Gallo and fresh cilantro.
Serve the loaded potato skin nachos with Salsa, Sour Cream, lime wedges, and sliced Avocado on the side.