Preheat oven to 350°F (175°C).
In a shallow bowl or dish, combine 2 cups flour, 2 teaspoons seasoned salt, 1/2 teaspoon cayenne pepper, and 1/2 teaspoon ground black pepper. Stir to mix evenly.
Prepare 2 pounds chicken wings: if whole, cut each wing at the joints into drumette and wingette sections and discard the wing tips (or keep tips for stock). Pat the wing pieces dry with paper towels.
Dredge the wings in the flour mixture, coating all sides; shake off excess flour. Arrange the coated wings in a single layer on a wire rack set over a baking sheet (use two racks or two sheets if needed so wings are not touching).
Bake the wings at 350°F for 35–45 minutes, turning once halfway through, until the wings are browned and an instant-read thermometer inserted into the thickest part registers 165°F (74°C).
While the wings bake, make the sauce: in a small saucepan combine 1 cup Frank's Red Hot Sauce, 1/2 cup butter, 1 1/2 tablespoons white vinegar, 1 teaspoon Worcestershire sauce, 1 tablespoon garlic powder, and 1/4 teaspoon cayenne pepper. Heat over low–medium heat, whisking, until the butter is melted and the sauce is smooth. Do not boil; remove from heat once combined.
When the wings are done, transfer them to a large bowl. Pour the hot sauce over the wings.
Toss and turn the wings in the bowl until they are fully and evenly coated with the sauce.
Serve the wings immediately.